Anthropic借助Claude解析原核生物来源的首个3D vault颗粒结构

> We’re sharing how our biology research team worked with Claude to map the first 3D structure of a vault particle from bacterial life. > > Vault particles are a longstanding mystery. They are barrel-shaped objects, among the largest protein structures found in our cells. They were… > > — Anthropic (@AnthropicAI) November 4, 2026 Anthropic’s team searched approximately 15 billion predicted protein sequences for distant relatives. The search identified potential vault proteins across 29 major bacterial groups and four groups of archaea. The researchers selected 44 candidates for laboratory testing. ## Inside the bacterial vault [...] Scientists have mapped the first three-dimensional structure of a vault particle linked to bacterial life, uncovering a previously unexplored branch of these mysterious protein assemblies. The discovery could give researchers a simpler way to investigate structures found in human cells. Anthropic’s biology research team used Claude throughout the inv

Anthropic says the optimized process took about 90 minutes from cells to microscopy grid, compared with about three days using its described conventional method. 3. 03 A first full model was ready in 34 hours, Anthropic reports, but final maps took about a week and the analysis used hundreds of GPUs. Biologists have a simpler system for investigating one of the cell’s enduring mysteries: giant, hollow protein shells called vaults. On November 4, Anthropic said its researchers, working with Claude, resolved the first 3D vault structure from prokaryotic life. The particle contains 96 copies of a virus protein, but its biological purpose remains unknown. [...] A protein from a bacteria-infecting virus has assembled into a complete vault: a hollow shell built from 96 identical copies. Anthropic says this is the first complete vault structure reported from prokaryotic life, and it gives researchers a simpler way to probe how these mysterious structures form. The protein, called L05, co

# Investigating vault particles with Claude Collage illustration pairing vintage measuring scales over a black-and-white photograph with a green print of a ribbed, vaulted cathedral ceiling. Team Science > We’re sharing another finding from Anthropic’s biology research lab: the first 3D structure of a vault particle found in prokaryotic cells. Vaults are large, hollow barrels of protein found in cells across the tree of life, and their function is still unknown. Below, we describe how Claude helped at each step of this research: searching across sequence literature, optimizing a method of isolating particles, and mapping the vault’s structure. More information is in our preprint, which we’ve submitted to bioRxiv; we’ll update the link as soon as it goes live. [...] Interested in whether Claude could help make progress on this long-standing open problem, our biology research team has been investigating vaults. We haven’t yet determined their biological function, but we did find t

Tech Twitter # Tech Twitter // the front page of tech Trending//Main Characters//Launches//Time Travel//Agents You opened a post// Nov 4 ## Mapping a bacterial vault particle's structure with Claude Anthropic @AnthropicAI We’re sharing how our biology research team worked with Claude to map the first 3D structure of a vault particle from bacterial life. Vault particles are a longstanding mystery. They are barrel-shaped objects, among the largest protein structures found in our cells. They were first discovered by Leonard Rome and Nancy Kedersha in 1986, but their function remains unknown. With Claude, we’ve found r Sign in to read the rest of this post. Continue with X Adds you to the daily email. Unsubscribe anytime. Just want the daily email?Subscribe

We’re sharing how our biology research team worked with Claude to map the first 3D structure of a vault particle from bacterial life. Vault particles are a longstanding mystery. They are barrel-shaped objects, among the largest protein structures found in our cells. They were first discovered by Leonard Rome and Nancy Kedersha in 1986, but their function remains unknown. With Claude, we’ve found results that might bring us closer to solving that mystery. Until now, vaults were only known in the cells of complex things like animals and plants. We have shown that similar proteins from bacteria (and the viruses that infect them) can also assemble into vaults. Finding the structures in these simpler forms of life may make it easier to investigate their function in our own cells. For our life [...] We’re sharing how our biology research team worked with Claude to map the first 3D structure of a vault particle from bacterial life. Vault particles are a longstanding mystery. They are barrel-s

# Vaibhav Sisinty on X: "Claude helped map the first 3D structure of a vault particle from bacterial life. Vault particles are barrel-shaped structures inside cells, among the largest protein structures found there, and scientists have long wondered what they actually do. Anthropic's biology team had Claude search 15 billion predicted proteins to find vault relatives, then worked through candidates in the lab until one formed a complete particle. A first structural model was ready in 34 hours, work the team estimates would normally take weeks. The catch is the mystery is not solved. What vault particles do is still unknown, and the team plans to release the structures so other scientists can help figure it out. That is the point worth noticing. The discovery is real, but the bigger story [...] ## Conversation @VaibhavSisinty @AnthropicAI ## Log in or sign up for X See what’s happening and join the conversation ## Relevant people Avatar ## What’s happening @VaibhavSisinty @Anthro